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Health Dangers of Oxalates

Health Dangers of Oxalates

Health Dangers of Oxalates

Health Dangers of Oxalates
Health Dangers of Oxalates

In our look at the Health Dangers of Plant-Based Foods we turn to oxalates. These are especially troublesome to the “health conscious.” It is nearly universally accepted that a large spinach salad topped with almonds and sesame seeds is a healthy meal. It goes without question that these leafy greens, that the cruciferous vegetables, that soy, and seeds are health foods. But contrary to popular belief, plants don’t want to be eaten. They use various mechanisms to deter predation, one of which is oxalates. Here we’re going to look at the health dangers of oxalates.

Health Dangers of Oxalates: Plant Growth and Protection

Plants have “motivations” for their survival, not human health. To protect themselves, plants use phytochemicals to deter predators from eating them. These special molecules fight back against fungi, insects, and animal predators – including us humans. Oxalates are such a molecule.

Because oxalates form into sharp crystal-like structures, they can prick a predator’s mouth, detering predation. Further, they prevent the absorption of minerals, deplete vitamins, and can bioaccumulate damaging tissues and organs. [rr]

Oxalate an an Antinutrient

Plants load their seeds with nutrition for the baby plant and they use oxalate as a way to store calcium for the new offspring. When seeds start to germinate they split off the oxalic acid which frees the calcium for the baby plant.

While oxalate is used as a calcium storage mechanism for plants, it’s a nutrient blocker (an antinutrient) for predators.

For example, many people think spinach is a good source of calcium. If you look at the label that’s what it will tell you. But it’s misguided. The calcium in spinach is pretty much useless. It’s all tied up in oxalate. And this is true for all high-oxalate foods.

There is a big difference in the nutrition measured in food and the nutrition that the body can actually absorb and use (bioavailability).

This is where standard nutrition guidelines start falling short.

If we eat 100% of our RDI (recommended daily intake) of calcium from spinach, but 100% of it is tied up in oxalate, we actually get 0% of the RDI.

Making matters worse, certain foods, like those high in oxalates, can increase the amount of a nutrients we need.

For example, if I were to eat a large bowl of spinach every day for lunch, I would increase my need for certain vitamins and minerals like b1 (thiamine), b6 (pyridoxine), and b7 (biotin).

Similarly to how phytic acid is a mineral thief, oxalic acid is a magnet for minerals, especially calcium. Oxalic acid grabs calcium and forms calcium oxalate – the main ingredient in kidney stones. [r, r]

Oxalate Bioaccumulation

Oxalate isn’t just an antinutrient that depletes calcium and iron, stealing essential vitamins and minerals.

While impairing nutrition as an antinutrient isn’t a good thing, oxalates ability to bioaccumulate and cause tissue and organ damage is what most people need to consider.

Oxalates can be toxic to humans in acute and chronic amounts. And while you can die if you eat too much oxalate at a single sitting, the toxicity is often more insidious. [r]

These oxalate crystals build up into bigger and bigger crystals. They bioaccumulate. As they accumulate the body deposits these sharp crystals throughout the body – in joints, muscles, and especially the kidneys. [r, r, r, r, r, r]

Oxalate Damage

With oxalate crystals growing and stored throughout the body, muscles start aching, eyes, ears, mouth, and throat can burn, and stones form in the kidneys.

Oxalate crystals cause renal damage; they are neurotoxic; they activate the immune system, upset the GI tract, deplete glutathione, and corrode connective tissue (via interference with hyaluronic acid).

Oxalates can impact nearly every bodily system. [rrrrrrr, r, r, r]

  • They can cause neurological symptoms which disturb sleep and adversely affect coordination, memory, learning, and concentration.
  • They cause pain via mast cell degranulation and histamine release.
  • Mysterious vulva pain, fibromyalgia, and carpal tunnel syndrome can all have oxalates causing or worsening the symptoms.
  • Increased calcium excretion and increased oxalic acid excretion ride hand-in-hand and are linked with osteoporosis.
  • Common practice for autism treatment is the elimination of oxalate-containing foods (as well as gluten, casein and soy).
  • Oxalates have even been implicit in breast cancer.

Oxalate Absorption

Absorption of oxalate differs from person to person. For some, oxalate is largely broken down in the gut and eliminated without causing issues. In others, a large percentage of consumed oxalate is absorbed.

Someone with a compromised gut, aka “leaky gut,” can see increased absorption of oxalate.

Not only does “leaky gut” allow more oxalate to get in, oxalate can be implicit in exacerbating leaky gut. The needle shape of oxalate crystals can perforate mucus membrane cells damaging the gut and increasing “leakiness”. [r, r, r, r, r, r]

Health Dangers of Oxalates: High-Oxalate Foods

It’s not only spinach pricks that can hurt you.

Many of the cruciferous vegetables like kale, cauliflower, and broccoli have high concentrations of oxalate.

Other culprits include chocolate, most nuts (especially cashews and almonds that are popular among the health conscious), and seeds like sesame and poppy seeds. [rr, r]

One of the worst offenders is soy. I remember when I was soy stupid – clueless that my soy protein shakes were loaded with oxalates.

Berries and beans. Potatoes and sweet potatoes. Okra. Swiss chard. Anything in the buckwheat family like sorrel. All high in oxalates.

Sorrel is actually worse than spinach and kale. And for some reason it is popular in fancy restaurants. There is a case report of a man who ordered sorrel soup for dinner. Two hours later he died in the hospital from acute oxalic acid poisoning. [r]

The man had poor metabolic health. He was obese and diabetic. And poor metabolic health further impairs the handling of oxalate. Yet, today we encourage obese diabetic patients to eat diets that are high in oxalates.

Health Dangers of Oxalates: Insidious Impact

Like other plant toxins, we don’t know (with any degree of accuracy) the frequency and degree of harm from oxalates thanks to a general lack of awareness. It often takes bioaccumulation to the point of an acute kidney injury until a healthcare practitioner even considers oxalate as a potential culprit. [r, r]

Sometimes patients with oxalate problems are asymptomatic until they find themselves trying to pass a kidney stone.

Sometimes mysterious lingering pain gets diagnosed as fibromyalgia or carpal tunnel syndrome without any knowledge as to why the pain is occuring.

Clearing the Crystals

Sometimes oxalate toxicity symptoms present when eating high-oxalate foods. But often they don’t. And sometimes symptoms don’t present until one stops eating oxalates.

For example, a flare up of pain may be from the release of stored oxalate that’s been consumed over a period of time.

The reason is that you have all these oxalate crystals accumulated in tissues, and now that you aren’t eating them, the body can process out the stores. The tissues start dissolving big crystals down into smaller crystals (and into their ion form) which are what cause much of the cellular damage and pain. But once back out into the bloodstream they can be excreted through the urinary tract. [r]

This process of breaking down and unloading the stored crystals for excretion can cause the same or worse symptoms than when they were originally eaten (a false positive reaction).

You’ve got to “re-eat” all that spinach.

Health Dangers of Oxalates: What (not) to do

Oxalate damage is from toxicity. It’s not a food sensitivity or allergen. So reversal of oxalate toxicity is a 2-step process:

  1. Stop eating it
  2. Excrete that which is stored up

Unfortunately, there isn’t a good way to determine how much oxalate damage you might have or how well you process them in general. Urine test are unreliable and a biopsy of tissue from the kidney is quite invasive. [r]

It’s also hard to correlate oxalate consumption with symptoms. As mentioned, you may be asymptomatic with insidious accumulative damage that doesn’t present until a serious event like kidney failure, or symptoms may only arise after you stop eating them.

The best thing you can do is limit the amount of oxalates you eat.

The major source of oxalates are from plant-based foods. But oxalate is also a byproduct of metabolism.

For example, excess Vitamin C can get converted to oxalate. Just another reason megadoses of Vitamin C might not be a good idea.

Cooking to Remove Oxalates

There’s also a false notion that you can just cook the oxalate out of your vegetables. This doesn’t work.

Oxalate and oxalic acid crystals are so durable that they are used by paleontologists to determine what people ate thousands of years ago. They aren’t destroyed by heat or cooking.

The one thing that can help is boiling these vegetables in water. The soluble parts of oxalic acid that aren’t crystalized can leach out into the water. So if you boil your broccoli to mush you can reduce the oxalate concentration by maybe a third. [r]

Low Oxalate Diet

My Dad recently sent me this picture of his new Low Oxalate Meal Plan, given to him by his nephrologist after another battle with kidney stones.

Low Oxalate Diet

I always appreciate it when a healthcare provider gives information on prevention and root causes.

If you go through this Low Oxalate Meal Plan, what you’ll notice is that when limiting oxalates you necessarily start moving to a meat-based diet.

My Dad is now using the Meat Health Method to transition into his low oxalate diet.
I talk more about this method in the Meat Health Masterclass.

There are a lot of misconceptions around “healthy” food, perhaps epitomized by the “green smoothie cleanse.” People want to do the right thing, but are often “stabbing” themselves in the foot (or more accurately the kidney).

But a green smoothie “cleanse” is more likely to lead you to needing an oxalate cleanse.

[NOTE: You can now access the complete “Health Dangers of a Plant-Based Diet” series here]:

Resources [r]: Many resources were used in the research and writing of this article. It’s often impossible for me to cite everything that has helped draw the conclusions presented. But I wanted to make a special note on the “Journal of Evolution and Health” Volume 2, Issue 3, 5/2018 and it’s references that were especially helpful. This is a great place to start if interested in learning more about oxalates.

146 Replies to “Health Dangers of Oxalates”

  1. Hi Kevin.
    Thx for your article n replys. I have severe oxalate poisioning that has been the cause of my fibromyalgia n many other conditions.
    I was on a strict red meat n salt diet for 3-4 months…n then moved back into additional options due to extreme fatigue and no huge improvents. I used store beef. My question is if severely oxalte overloaded…would eating grain fed meat be loaded with oxalates too…adding to the overload?
    I will try again with grassfed beef.

    1. Hi Kevin,

      I was wondering if, as mentioned, oxalates cause histamine reactions as have a very itchy scalp…been this way for months.

      I’ve been on a mostly carnivore based diet now for 3.5 weeks…but, was eating raspberries and avodado daily before that for about 2 years! If they are the cause, wondering…now that I’ve stopped with high (unconscious) consumption of oxalates, will the itching get worse before better? Does hair fall relate to the same thing…and lastly, are sebaceous cysts also a result of oxalates?

      Thanks so much.

      1. Hi Sandra!
        I, too, have itchy scalp and thinning hair, along with other symptoms mentioned in preceding comments. So I’m thinking that’s not a coincidence. I’ve looked at lists of high oxalate foods, and as other people have stated, seems it changes from one website to another. One cup of raspberries has 48 mg of oxalates, one avocado 19, which seems low when compared to one cup of cooked spinach, 1510mg or raw 656. While it seems raspberries are low in oxalates, I did see them on a list of high oxalate foods. In fact all berries, except strawberries were on that list.
        I have had chronic hives for a few years now, which seems to have gotten better since eliminating some of the higher oxalate foods, such as spinach, okra, all potatoes, almonds (highest), and any nuts, except pistachios (lowest, and ok on Keto). I still eat avocados regularly (lower on the list), because I’ve been eating mostly keto for the past year, and while I’ve seen great improvement in many of my health concerns, the oxalate symptoms, though better, still persist. I’ve been considering going carnivorous, but haven’t yet committed, as I have difficulty letting go of everything all at once.
        During a conversation with my Sister a couple of days ago, she exclaimed, “Oh my goodness! What’s left for you to eat?!”
        I guess the answer is meat. 🤷🏻‍♀️

        God bless you in your endeavor to get healthy!

        1. Some lists, eg the Harvard list posted here, have strawberries and avocados in high/very high oxalate category too. I understand that categorization can be affected by the specie/cultivar. But I had a big reaction (my typical oxalate reaction) to some avocado. Mind you, avocado is also high in salicylates, which is another toxic. I am yet to research effects of salicylates, and assess my reaction, if any, to it.

  2. Hi! This is all very interesting…I only just recently read about oxalates when I saw an article on foods that can be toxic if eaten too much and I thought I’d poke around to find out more about them, saw your info and now I’m left wondering how you get the vitamins and minerals that come from vegetables if, as it seems from this, you don’t eat anything but meat? Sorry if that’s a very simple question, but I’m curious about what it means to completely cut veggies (and fruit?) out of your diet. I’m not sure I could ever do that, ha… Thanks!

  3. Hi Kevin, thanks for the informative article. Could it be that oxalates are linked with heavy tartar buildup behind lower front teeth? I’ve been consuming nuts 25% of my diet plus peanut butter and vegetables and I always notice a heavy tartar buildup into my teeth despite of good oral care routine.

    1. Possible, but likely has more to do with mineral content and saliva flow (which can both be impacted by diet).

    2. I get what seems to be calcium deposits on my teeth as soon as I eat high oxalate foods, so much so that I now try to use this as a test for if a food has high oxalate, if this information is not available.

  4. Thank you so much for this. I only recently put two and two together. I’ve been sick for 20 years but a couple years ago I took and antibiotic and started getting all over joint pain and organ issues I never had. Keeping track of what I reacted to I eventually ended up living on ground chicken and eggs. My body seemed to be in agony from nearly everything else. I’ve now determined after trying to add foods back in that I’m reacting to oxalates AND purines resulting in a very small list of foods that don’t cause utter agony. And the lists are all over the place. One list will say broccoli is ok then another says it’s high. Ultimately I just want to be able to get the nutrients my body needs and I don’t know how with my body reacting to everything. Add in autoimmune and MTHFR. Oh wasn’t it lovely when we could just eat food and not be poisoned by everything? Those were the days.

    1. You sound like me, Bonnie. My body now seems to have an allergic reaction to oxalates, but I count this as lucky cos this is what made me come around to the reality of oxalates. I also now live on ground chicken and eggs, but able to eat a number of other foods too:

      ground meat, chicken, turkey, beef, fish, salmon, tilapia, stockfish, crayfish, seafood, egg, cow/goat milk, cheese, yogurt, white chocolate, lettuce, cabbage^, bok choy, rapini, bitterleaf, green peas, corn*, bell pepper, onions*, garlic*, ginger*

      ^ a little as affects thyroid

      1. …watermelon, honeydew, cantaloupe, yellow melon, papaya, banana, peeled apple~, acorn squash, spaghetti squash, white potatoes, white rice, white bread, rye bread, rye flour, egg noodles, corn tortillas, water chestnuts, coconut, coconut milk blackeyed beans, moong, honey, humus*, butter, olive oil, palm oil, sesame oil, pineapple juice, some teas, some spices

        * a little due to medium or high oxalate content
        ~ some varieties

    2. Amen Bonnie! It seems to me that food became my enemy after going through menopause. That’s when a range of symptoms showed up. Of course, that is also about the time I started juicing spinach, beets, carrots, and parsley. I think it was the perfect storm. You would think I would have developed kidney stones, but I didn’t (confirmed by an ultrasound). I think what prevented the stones was my daily mug of hot lemon water. But apparently it didn’t prevent the oxalates from building up in the rest of my body. I am five weeks into the low oxalate diet and still dumping like crazy.

  5. Hi Kevin,
    You recently said you were writing about gout among other things. Any idea when you are going to release that research?
    I recently just started getting high uric acid on my blood tests. Started eating mostly red meat in January 2019. All I read is stop eating red meat. I don’t want to stop as I have never felt better eating meat.
    Thanks,

    1. Hi Mike – yes it will be sent out in the next few weeks – if you want the cliff notes on the gout section: it’s not the meat / protein.
      Fructose / alcohol are 2 of the biggest culprits. There’s a lot more to it, but feel bad keeping you waiting!

  6. I passed two kidney stones in the past two years, it’s been a year since I passed the second one and still have ocassionall blood in the urine about every two month or so…all my kidney test and blood work are in the normal range no indication of kidney disease and no sighs of new stones I’ve been eating carnivorish and low oxalates.. could the ocassionall blood be crystals leaving the body?

    1. I would talk with a nephrologist or urologist if you’ve been eating low oxalate for over a year and still having issues.

  7. So, if we take a calcium citrate supplement or 2 oz raw cheese whenever we eat a portion of high oxalate vegetables, it would not only bind to the oxalates but allow us to absorb the calcium iron and zinc from the vegetable itself?
    Thanks!

  8. Any idea how long it may take for the body to completely “dump” the oxalates? Is there any way to speed up the process? I am trying a 30 day carnivore diet-however I don’t know about giving up coffee completely! Also, do you recommend magnesium supplements?
    Thanks!

    1. Hi Amy, unfortunately this is very different for everyone (depending on many factors like extent of oxalate buildup).
      If you read the 30 day guide to going full carnivore (https://meat.health) than you’ll see how I recommend handling coffee.
      Magnesium can help people during the transition (supplement guide is also in the 30 day guide). All the best! 🙂

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