Health Dangers of Oxalates

Health Dangers of Oxalates

Health Dangers of Oxalates

Health Dangers of Oxalates
Health Dangers of Oxalates

In our look at the Health Dangers of Plant-Based Foods we turn to oxalates. These are especially troublesome to the “health conscious.” It is nearly universally accepted that a large spinach salad topped with almonds and sesame seeds is a healthy meal. It goes without question that these leafy greens, that the cruciferous vegetables, that soy, and seeds are health foods. But contrary to popular belief, plants don’t want to be eaten. They use various mechanisms to deter predation, one of which is oxalates. Here we’re going to look at the health dangers of oxalates.

Health Dangers of Oxalates: Plant Growth and Protection

Plants have “motivations” for their survival, not human health. To protect themselves, plants use phytochemicals to deter predators from eating them. These special molecules fight back against fungi, insects, and animal predators – including us humans. Oxalates are such a molecule.

Because oxalates form into sharp crystal-like structures, they can prick a predator’s mouth, detering predation. Further, they prevent the absorption of minerals, deplete vitamins, and can bioaccumulate damaging tissues and organs. [rr]

Oxalate an an Antinutrient

Plants load their seeds with nutrition for the baby plant and they use oxalate as a way to store calcium for the new offspring. When seeds start to germinate they split off the oxalic acid which frees the calcium for the baby plant.

While oxalate is used as a calcium storage mechanism for plants, it’s a nutrient blocker (an antinutrient) for predators.

For example, many people think spinach is a good source of calcium. If you look at the label that’s what it will tell you. But it’s misguided. The calcium in spinach is pretty much useless. It’s all tied up in oxalate. And this is true for all high-oxalate foods.

There is a big difference in the nutrition measured in food and the nutrition that the body can actually absorb and use (bioavailability).

This is where standard nutrition guidelines start falling short.

If we eat 100% of our RDI (recommended daily intake) of calcium from spinach, but 100% of it is tied up in oxalate, we actually get 0% of the RDI.

Making matters worse, certain foods, like those high in oxalates, can increase the amount of a nutrients we need.

For example, if I were to eat a large bowl of spinach every day for lunch, I would increase my need for certain vitamins and minerals like b1 (thiamine), b6 (pyridoxine), and b7 (biotin).

Similarly to how phytic acid is a mineral thief, oxalic acid is a magnet for minerals, especially calcium. Oxalic acid grabs calcium and forms calcium oxalate – the main ingredient in kidney stones. [r, r]

Oxalate Bioaccumulation

Oxalate isn’t just an antinutrient that depletes calcium and iron, stealing essential vitamins and minerals.

While impairing nutrition as an antinutrient isn’t a good thing, oxalates ability to bioaccumulate and cause tissue and organ damage is what most people need to consider.

Oxalates can be toxic to humans in acute and chronic amounts. And while you can die if you eat too much oxalate at a single sitting, the toxicity is often more insidious. [r]

These oxalate crystals build up into bigger and bigger crystals. They bioaccumulate. As they accumulate the body deposits these sharp crystals throughout the body – in joints, muscles, and especially the kidneys. [r, r, r, r, r, r]

Oxalate Damage

With oxalate crystals growing and stored throughout the body, muscles start aching, eyes, ears, mouth, and throat can burn, and stones form in the kidneys.

Oxalate crystals cause renal damage; they are neurotoxic; they activate the immune system, upset the GI tract, deplete glutathione, and corrode connective tissue (via interference with hyaluronic acid).

Oxalates can impact nearly every bodily system. [rrrrrrr, r, r, r]

  • They can cause neurological symptoms which disturb sleep and adversely affect coordination, memory, learning, and concentration.
  • They cause pain via mast cell degranulation and histamine release.
  • Mysterious vulva pain, fibromyalgia, and carpal tunnel syndrome can all have oxalates causing or worsening the symptoms.
  • Increased calcium excretion and increased oxalic acid excretion ride hand-in-hand and are linked with osteoporosis.
  • Common practice for autism treatment is the elimination of oxalate-containing foods (as well as gluten, casein and soy).
  • Oxalates have even been implicit in breast cancer.

Oxalate Absorption

Absorption of oxalate differs from person to person. For some, oxalate is largely broken down in the gut and eliminated without causing issues. In others, a large percentage of consumed oxalate is absorbed.

Someone with a compromised gut, aka “leaky gut,” can see increased absorption of oxalate.

Not only does “leaky gut” allow more oxalate to get in, oxalate can be implicit in exacerbating leaky gut. The needle shape of oxalate crystals can perforate mucus membrane cells damaging the gut and increasing “leakiness”. [r, r, r, r, r, r]

Health Dangers of Oxalates: High-Oxalate Foods

It’s not only spinach pricks that can hurt you.

Many of the cruciferous vegetables like kale, cauliflower, and broccoli have high concentrations of oxalate.

Other culprits include chocolate, most nuts (especially cashews and almonds that are popular among the health conscious), and seeds like sesame and poppy seeds. [rr, r]

One of the worst offenders is soy. I remember when I was soy stupid – clueless that my soy protein shakes were loaded with oxalates.

Berries and beans. Potatoes and sweet potatoes. Okra. Swiss chard. Anything in the buckwheat family like sorrel. All high in oxalates.

Sorrel is actually worse than spinach and kale. And for some reason it is popular in fancy restaurants. There is a case report of a man who ordered sorrel soup for dinner. Two hours later he died in the hospital from acute oxalic acid poisoning. [r]

The man had poor metabolic health. He was obese and diabetic. And poor metabolic health further impairs the handling of oxalate. Yet, today we encourage obese diabetic patients to eat diets that are high in oxalates.

Health Dangers of Oxalates: Insidious Impact

Like other plant toxins, we don’t know (with any degree of accuracy) the frequency and degree of harm from oxalates thanks to a general lack of awareness. It often takes bioaccumulation to the point of an acute kidney injury until a healthcare practitioner even considers oxalate as a potential culprit. [r, r]

Sometimes patients with oxalate problems are asymptomatic until they find themselves trying to pass a kidney stone.

Sometimes mysterious lingering pain gets diagnosed as fibromyalgia or carpal tunnel syndrome without any knowledge as to why the pain is occuring.

Clearing the Crystals

Sometimes oxalate toxicity symptoms present when eating high-oxalate foods. But often they don’t. And sometimes symptoms don’t present until one stops eating oxalates.

For example, a flare up of pain may be from the release of stored oxalate that’s been consumed over a period of time.

The reason is that you have all these oxalate crystals accumulated in tissues, and now that you aren’t eating them, the body can process out the stores. The tissues start dissolving big crystals down into smaller crystals (and into their ion form) which are what cause much of the cellular damage and pain. But once back out into the bloodstream they can be excreted through the urinary tract. [r]

This process of breaking down and unloading the stored crystals for excretion can cause the same or worse symptoms than when they were originally eaten (a false positive reaction).

You’ve got to “re-eat” all that spinach.

Health Dangers of Oxalates: What (not) to do

Oxalate damage is from toxicity. It’s not a food sensitivity or allergen. So reversal of oxalate toxicity is a 2-step process:

  1. Stop eating it
  2. Excrete that which is stored up

Unfortunately, there isn’t a good way to determine how much oxalate damage you might have or how well you process them in general. Urine test are unreliable and a biopsy of tissue from the kidney is quite invasive. [r]

It’s also hard to correlate oxalate consumption with symptoms. As mentioned, you may be asymptomatic with insidious accumulative damage that doesn’t present until a serious event like kidney failure, or symptoms may only arise after you stop eating them.

The best thing you can do is limit the amount of oxalates you eat.

The major source of oxalates are from plant-based foods. But oxalate is also a byproduct of metabolism.

For example, excess Vitamin C can get converted to oxalate. Just another reason megadoses of Vitamin C might not be a good idea.

Cooking to Remove Oxalates

There’s also a false notion that you can just cook the oxalate out of your vegetables. This doesn’t work.

Oxalate and oxalic acid crystals are so durable that they are used by paleontologists to determine what people ate thousands of years ago. They aren’t destroyed by heat or cooking.

The one thing that can help is boiling these vegetables in water. The soluble parts of oxalic acid that aren’t crystalized can leach out into the water. So if you boil your broccoli to mush you can reduce the oxalate concentration by maybe a third. [r]

Low Oxalate Diet

My Dad recently sent me this picture of his new Low Oxalate Meal Plan, given to him by his nephrologist after another battle with kidney stones.

Low Oxalate Diet

I always appreciate it when a healthcare provider gives information on prevention and root causes.

If you go through this Low Oxalate Meal Plan, what you’ll notice is that when limiting oxalates you necessarily start moving to a meat-based diet.

My Dad is now using the Meat Health Method to transition into his low oxalate diet.
I talk more about this method in the Meat Health Masterclass.

There are a lot of misconceptions around “healthy” food, perhaps epitomized by the “green smoothie cleanse.” People want to do the right thing, but are often “stabbing” themselves in the foot (or more accurately the kidney).

But a green smoothie “cleanse” is more likely to lead you to needing an oxalate cleanse.

[NOTE: You can now access the complete “Health Dangers of a Plant-Based Diet” series here]:

Resources [r]: Many resources were used in the research and writing of this article. It’s often impossible for me to cite everything that has helped draw the conclusions presented. But I wanted to make a special note on the “Journal of Evolution and Health” Volume 2, Issue 3, 5/2018 and it’s references that were especially helpful. This is a great place to start if interested in learning more about oxalates.

147 Replies to “Health Dangers of Oxalates”

  1. Hi Kevin
    Thanks for your article on oxalates..recently been on a banting way of eating (google banting or professor tim noakes). Very big jn south africa. I found my legs and ankles were swelling up. I have fat legs anyway (genetic). I decided to stop the banting and just eat whatever. Its boiling hot now in israel but no swelling. Is this just a coincidence.
    Banting is low carbs (<25g pd) medium protein high fat.
    I have gone off fats now as i introduced carbs. Put on a bit of weight now too. But at least my legs toes and ankles are not swelling up.
    Any ideas?

    1. Hi Tanya, I’m not entirely sure what you are asking…if it is “can modern/western/american diet cause issues” well then I would answer “yes” to that.

  2. Hi Kevin !
    Thanks for the info. Can you tell me if you’ve found a link between high oxalates and vertigo? Have a great day ?

    1. There is a gene mutation (Slc26a4) associated with oxalate stone formation in the inner ear which could result in hearing loss and vestibular dysfunction.

      1. What does this actually mean, would that be ringing in the ear. Another question. can to much oxalates cause gout.

  3. Hi Kevin,

    Can Oxalates leave the body through exiting your skin? I have these “little crystals ” it seems to be coming out of my skin. They are very small and they feel like a pebble of sand but they look like crystals. They are very painful when coming out and I also get extremely itchy and all this usually happens at night. Can you please give me any incite or information about this? No one seems to know what im talking about not even doctors.

    1. Hi. I’m wondering if you got any feedback about the crystals coming out of your skin. I know exactly what your talking about and get them myself. Also super puzzled about what this may be.

  4. Kevin, do you have any concern about stored oxalate leaving the body harming kidneys on its way out? I was watching a Sally K Norton interview on youtube and she made a few comments that got me thinking.

    1. In severe cases (and people with pre-existing kidney disease) it could potentially be a problem, I think for most people with healthy kidneys, it’s not a big issue.

  5. The supplement Kidney COP (amazon) works wonders. It technically helps with kidney stone sufferers but has worked wonders for my oxalate issues. I have pain in different places and my tongue tingles – SUPER annoying. The kidney cop helps bind the crystals to calcium for excretion. I’d also reccomend to heal your GI tract with a supplement. I bought one off Dr. Gundry’s website and a probiotic. Meat and cheese will help in the mean time but you need the healthy foods long term.

  6. I did a little searching after reading this. I am hoping my sinuses and my chronically tight forearm,bicep and shoulder improve.

  7. Hi Kevin. Awesome article Thankyou, I am 14 days into a carnivore diet I started to treat autoimmune (ulcerative colitis and alopecia) and now I am having a terrible flare up of joint pain in my hands and feet, something I would get often when feeling inflamed. Do you suppose my body is dumping oxalates? I did used to be a vegan..for a year until I got so incredibly sick, I hoofed down the spinach and green smoothies!
    Or could this pain and discomfort be more of an adaption period.
    Thankyou for your time and your work.

    1. I would just be guessing, could be either.

      But either way, it sometimes comes down to weather the storm – wish I could be more helpful!

      1. Hi Kevin. Would you please delete my comment, it comes up in google search when my name is entered and I would just so prefer to keep my health private. Thankyou

  8. Do oxylates cause calcification of tendons and ligaments? I recently tore my rotator cuff muscle in my shoulder – diagnosed as calcific tendonitis and also have a partially calcified ligament in my jaw. I eat a lot of vegetables and much too much dark chocolate
    Do you think there is s connection and can the calcification be reversed?

    1. Oxalate causes something (I think calcium compound) to deposit on joints. Dark chocolate used to cause my spinal cord to ache so much I could hardly turn my neck and/or back.

  9. Also, do oxalates dissolve in pure ethyl alcohol? I make a Chaga extract with it to help fight my daughters high blood sugar

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